The game is the 116th meeting between the Quakers and the Tigers.
Harvard currently sits undefeated atop the Ivy League with an 8-0 overall record.
Last season against Cornell, O'Brien set the Penn record for the most passing touchdowns in a game.
Penn will look to establish the run against the Bears, who let up 30 points last week.
Senior wide receiver Jared Richardson was one yard short of breaking a career-high 191 receiving yards.
Special teams and defense lifted Penn football to a 36-24 victory.
Solutions by The State News
