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Tuesday, Feb. 3, 2026
The Daily Pennsylvanian

Penn Medicine liable for $12.25 million in cancer misdiagnosis suit, Philadelphia jury says

09-05-25 Penn Medicine (Chenyao Liu).jpg

A Philadelphia jury reached a $35 million verdict against Penn Medicine and Main Line Health after a cancer misdiagnosis led the plaintiff to undergo a medically unnecessary full hysterectomy.

Penn and physician Janos Tanyi were found liable for 35% — or $12.25 million — of the total verdict. The decision came after the plaintiff, Isis Spencer, filed a complaint in January alleging “negligent and outrageous conduct.”

The suit named named Penn, Penn Med, the University’s health system, and Tanyi as defendants.

“I hope this verdict affirms the patient’s central role as the decision-maker and the physician’s obligation to provide them with all of the information and all of the options,” Glenn Ellis, Spencer’s lawyer, wrote in a statement to The Daily Pennsylvanian regarding the court’s decision. 

A Penn Med spokesperson wrote to the DP that they will be appealing the verdict. 

“We are disappointed by the jury’s verdict in this case that was unmoored to the evidence presented at trial on negligence and damages,” the spokesperson added. “Our physician reasonably relied on the pathology performed at a hospital outside our system that revealed a very aggressive cancer but which, unbeknownst to him, had been mixed up with another patient’s specimen.”

Spencer’s false-positive misdiagnosis was caused by contaminated biopsy slides at Main Line Health that mistook another person’s DNA for her own. After receiving the results, which indicated Spencer tested positive for grade 2-3 endometrial cancer, she sought a second opinion at Penn Med. 

Despite a biopsy taken at Penn Med returning negative for cancer, Spencer was still encouraged to undergo a total hysterectomy.

As part of the complaint, Spencer outlined the damages that occurred as a result of the misdiagnosis and the following hysterectomy. 

According to the filing, Spencer — who was 45 years old at the time of the procedure — faced “surgically induced early menopause,” which led to symptoms such as “dizziness, nausea, and horrible migraines.”

“None of the tests ordered by Dr. Tanyi confirmed that Ms. Spencer had cancer,” the complaint read. “Despite failing to confirm her diagnosis of endometrial cancer, Dr. Tanyi insisted that Ms. Spencer did in fact have endometrial cancer and refused to conduct any additional testing to help explain why the biopsies were conflicting.”

Despite tests being reported back to Tanyi as “within normal limits,” he proceeded to act in line with Main Line Health’s findings, the suit alleged. 

“Defendant Dr. Tanyi refused to conduct any additional testing and assured Ms. Spencer that the Main Line Biopsy was correct and that immediate surgery was her only real option,” the complaint read.

Spencer sought Tanyi’s opinion for the first time in February 2021. After performing multiple tests at the Hospital of the University of Pennsylvania, Tanyi completed the total hysterectomy in March 2021.

According to the complaint, Tanyi asked a nurse to relay news to Spencer that she had never had cancer later that month, after a postoperative pathological examination of her tissue failed to show the presence of any cancer.

“While being told that she had cancer was incredibly scary and life altering, finding out that she never had cancer and never needed a total hysterectomy has been unimaginably devastating,” the filing read. “Ms. Spencer now brings this lawsuit to hold the responsible healthcare providers accountable for their negligent and outrageous conduct.”

Main Line Health will not have to pay its portion of the verdict because it settled with Spencer in 2022 for an undisclosed amount. Penn Med plans to appeal the court’s ruling, according to The Philadelphia Inquirer.

The verdict marks the largest in Philadelphia this year for medical malpractice and comes after HUP faced the single largest malpractice award in Pennsylvania history in April 2023.

A Philadelphia judge upheld a record $183 million medical malpractice verdict against HUP in February 2024, rejecting Penn Med’s post-trial motions to have the case dismissed or the verdict reduced.